Why Aspirin and Caffeine Don’t Work for Hangovers

Why Aspirin and Caffeine Don’t Work for Hangovers

Woke up with a pounding headache and nausea after a night of drinking? Many people reach for over-the-counter painkillers like aspirin, assuming it’ll help. But is it actually safe—or even effective?

What Is a Hangover, Really?

When you consume alcohol, your body breaks it down into acetaldehyde—a toxic byproduct that causes inflammation, nausea, and fatigue. The liver uses ALDH2 enzymes to convert it into harmless acetic acid, but overconsumption overwhelms the system, leading to hangover symptoms.

Harvard Health: What causes a hangover—and how can you prevent it?

Aspirin and Alcohol: A Risky Combo

Aspirin is a non-steroidal anti-inflammatory drug (NSAID). While effective for pain relief, it can irritate the stomach and increase gastrointestinal bleeding risk, especially when alcohol is involved.

“Combining alcohol and NSAIDs increases the risk of stomach bleeding and liver damage.”
FDA Drug Safety Communication (2016)

Cleveland Clinic: Hangover Cures – Myths vs. Facts

Caffeine Doesn’t Help Either

Some hangover supplements use caffeine to deliver a short-term energy boost. However, caffeine doesn’t eliminate toxins and may worsen dehydration, anxiety, and heart rate irregularities.

Mayo Clinic: Hangover cures—Myth or fact?

Real Recovery Starts with Detox, Not Suppression

Hangovers are caused by toxic accumulation—not just pain. Therefore, the best path forward is to assist the body’s natural detox process, not to mask symptoms.

Many hangover products now focus on liver support and acetaldehyde breakdown using ingredients like milk thistle, kudzu, turmeric, ginger, and hovenia dulcis.

Comparing Hangover Supplements Scientifically

Below is a neutral comparison of four popular hangover products. This comparison is based on publicly available ingredient data and general consumer feedback, rated on a scale of 1 to 5.

Comparison of Popular Hangover Supplements

Note: This comparison does not endorse any specific product. Consumer experiences may vary based on individual health and metabolism.

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